![]() ![]() Histology (p=0.084), chemotherapy (p=0.49) and dose rate (p=1.00) did not have significant impact on local control. ![]() Dose (D90) to the High Risk Clinical Target Volume (CTV HR) (p=0.022, HR=0.967 per Gy) was significant for local control, whereas increasing CTV HR volume (p=0.004, HR=1.017 per cm 3), and longer OTT (p=0.004, HR=1.023 per day) were associated with worse local control. With a median follow up of 46months, 43 local failures were observed. The Cox Proportional Hazards model was applied to analyze the effect on local control of dose-volume metrics as well as overall treatment time (OTT), dose rate, chemotherapy, and tumor histology. Brachytherapy contouring and reporting was according to ICRU/GEC-ESTRO recommendations. This study analyzed 488 locally advanced cervical cancer patients treated with external beam radiotherapy±chemotherapy combined with IGABT. The purpose of this study was to provide evidence based recommendations for tumor dose prescription based on results from a multi-center patient series (retroEMBRACE). ![]() Currently, there is no consensus on dose prescription in image guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. ![]()
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